Millwall Football Club's unbeaten start to the Championship season was emphatically ended in a 5-1 defeat away to Southampton on Saturday, 29 August. The Lions now sit 10th in the table with six points from four games, a position they will aim to improve when they host Wrexham this week.

Mark Sykes gave Millwall a surprise early lead at St Mary's with his first goal for the club. That advantage was short-lived, however, as Southampton striker Cyle Larin scored twice to lead a comprehensive comeback for the hosts. Further goals from Finn Azaz, Leo Scienza, and Tom Fellows completed a dominant 5-1 victory for the Saints, who erased an early season points deduction with the win.

Manager Alex Neil will demand a stronger defensive response from his side. Millwall had kicked off the day with a perfect record before being "thumped" on the south coast. The result leaves the Lions with a goal difference of minus two, having scored six and conceded eight across their opening four league matches.

Ahead of the match against Wrexham, Millwall are dealing with a significant injury list. Massimo Luongo, Ryan Leonard, Alfie Doughty, Femi Azeez, Mathis Servais, Derek Mazou-Sacko, and Mihailo Ivanović are unavailable through injury. This will test the squad's depth as they look to bounce back from the heavy loss.

Phil Parkinson's Wrexham side arrive at The Den still searching for their first league win of the season, sitting 22nd in the Championship. The visitors strengthened late in the transfer window, bringing in defender Joe Worrall and midfielder Callum O'Hare. Millwall's own attacking threat has been led by Tairyk Arconte and Josh Coburn, who have two goals apiece this season.

The match against Wrexham will be broadcast live in the United Kingdom on Sky Sports+, with kick-off scheduled for 7:45 PM BST on Wednesday. For fans in the United States, the game will be available to stream on Paramount+. The fixture is a key opportunity for Millwall to return to winning ways in front of their home supporters.

Looking at the broader league picture, the defeat at Southampton leaves Millwall four points behind early leaders Swansea City. The immediate focus, however, is on securing three points against a struggling Wrexham side. The next challenge after that is a home game against Bolton Wanderers on Saturday, 5 September. Millwall's recent form reads two losses followed by two wins from their first four matches.